Sensitivity of newborn mice to carcinogenic agents.

The organ cultivation of lung tissue can be used to study the differences in the age reaction to blastomogenic action and to screen and test new carcinogenic agents, especially water-soluble substances. Comparison of the results of transplacental and immediate introduction of some blastomogenic compounds into organ cultures of the lung can provide new information on the mechanisms of their action. For example, my own observations incline to the opinion that the blastomogenic action of urethane is indirect.